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ABCB1 (MDR1) and ABCG2 (BCRP), both members of the ATP-binding cassette (ABC) transporter family, play a pivotal role in facilitating the diffusion of TMAO

Specifically, topiramate antagonizes the ability of kainate to activate the kainate/AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid

doi: 10.1016/j.cmet.2010.12.008 6 BarreaL.AnnunziataG.MuscogiuriG.LaudisioD.Di SommaC.MaistoM